Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy
نویسندگان
چکیده
منابع مشابه
Locally secreted Fc-OX40L is superior to systemic, antibody mediated, OX40 costimulation for combination immunotherapy
The dramatic clinical success of checkpoint inhibitory therapy (anti-CTLA-4 and anti-PD-1) in a small percentage of patients has highlighted the need to identify combination approaches that may increase the frequency of responders. Two immunotherapy modalities that are proposed to synergize both with each other, and with checkpoint inhibitors are therapeutic vaccines and T cell co-stimulators. ...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2018
ISSN: 2051-1426
DOI: 10.1186/s40425-018-0454-3